Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation
نویسندگان
چکیده
منابع مشابه
Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation
The proneural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation, although regulation of Ngn3 protein is largely unexplored. Here we demonstrate that Ngn3 protein undergoes cyclin-dependent kinase (Cdk)-mediated phosphorylation on multiple serine-proline sites. Replacing wild-type protein with a phosphomutant form of Ngn3 increases α cell ...
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The ubiquitin proteasome system (UPS) is known to be responsible for the rapid turnover of many transcription factors, where half-life is held to be critical for regulation of transcriptional activity. However, the stability of key transcriptional regulators of development is often very poorly characterised. Neurogenin 3 (Ngn3) is a basic helix-loop-helix transcription factor that plays a centr...
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During development, the pancreatic endocrine cells are specified within the epithelium. They will subsequently delaminate and migrate out of the epithelium in order to form the islets. Neurogenin3 (Ngn3) is a bHLH transcription factor that is responsible for differentiation of all endocrine cell types, but whether or not it has a role in their migration is still an open question. By using the c...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2017
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2017.04.004